Behaviorally inactive doses of mianserin antagonize the suppressant effect of lysergic acid diethylamide on a fixed-ratio operant.

@article{Dwoskin1983BehaviorallyID,
  title={Behaviorally inactive doses of mianserin antagonize the suppressant effect of lysergic acid diethylamide on a fixed-ratio operant.},
  author={Linda P. Dwoskin and Sheldon B. Sparber},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1983},
  volume={225 1},
  pages={77-84}
}
Male Sprague-Dawley rats were trained to respond for food reinforcement on a fixed-ratio 15 schedule. Low, behaviorally inactive, doses of mianserin (0.1-1.0 mg/kg) administered 30 min before the operant session antagonized the behavioral suppression induced by lysergic acid diethylamide (LSD; 50 micrograms/kg) administered immediately before the session… CONTINUE READING