Behavioral training reverses global cortical network dysfunction induced by perinatal antidepressant exposure.

@article{Zhou2015BehavioralTR,
  title={Behavioral training reverses global cortical network dysfunction induced by perinatal antidepressant exposure.},
  author={Xiaoming Zhou and J. Y. Lu and Ryan D. Darling and Kimberly L. Simpson and Xiaoqing Zhu and Fang Wang and Liping Yu and Xinde Sun and Michael Merzenich and Rick C. S. Lin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 7},
  pages={2233-8}
}
Abnormal cortical circuitry and function as well as distortions in the modulatory neurological processes controlling cortical plasticity have been argued to underlie the origin of autism. Here, we chemically distorted those processes using an antidepressant drug-exposure model to generate developmental neurological distortions like those characteristics expressed in autism, and then intensively trained altered young rodents to evaluate the potential for neuroplasticity-driven renormalization… CONTINUE READING
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