Behavioral time scale synaptic plasticity underlies CA1 place fields

  title={Behavioral time scale synaptic plasticity underlies CA1 place fields},
  author={Katie C Bittner and Aaron D Milstein and Christine Grienberger and Sandro Romani and Jeffrey C Magee},
Learning is primarily mediated by activity-dependent modifications of synaptic strength within neuronal circuits. We discovered that place fields in hippocampal area CA1 are produced by a synaptic potentiation notably different from Hebbian plasticity. Place fields could be produced in vivo in a single trial by potentiation of input that arrived seconds before and after complex spiking. The potentiated synaptic input was not initially coincident with action potentials or depolarization. This… CONTINUE READING
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