Behavioral suppression induced by cannabinoids is due to activation of the arachidonic acid cascade in rats
@article{Yamaguchi2001BehavioralSI, title={Behavioral suppression induced by cannabinoids is due to activation of the arachidonic acid cascade in rats}, author={Taku Yamaguchi and Yukihiro Shoyama and Shigenori Watanabe and Tsuneyuki Yamamoto}, journal={Brain Research}, year={2001}, volume={889}, pages={149-154} }
24 Citations
Endogenous cannabinoid, 2-arachidonoylglycerol, attenuates naloxone-precipitated withdrawal signs in morphine-dependent mice
- Biology, MedicineBrain Research
- 2001
Activation of brain prostanoid EP3 receptors via arachidonic acid cascade during behavioral suppression induced by Δ8‐tetrahydrocannabinol
- Biology, MedicineJournal of neurochemistry
- 2004
It is concluded that the suppression of lever‐pressing behavior by cannabinoid is due to activation of the prostanoid EP3 receptor through an elevation of PGE2 in the brain.
Decrease in prostaglandin level is a prerequisite for the expression of cannabinoid withdrawal: A quasi abstinence approach
- BiologyBrain Research
- 2005
Evaluation of the role of the arachidonic acid cascade in anandamide's in vivo effects in mice.
- Biology, MedicineLife sciences
- 2006
Induction of COX-2 expression by the endocannabinoid derivative R(+)-methanandamide.
- Biology, ChemistryAdvances in experimental medicine and biology
- 2003
Emerging evidence suggests that various cannabinoid actions are mediated via cannabinoid receptor-independent pathways, comprising activation of mitogen-activated protein kinases (MAPKs), alteration of intracellular calcium and cAMP levels, and inhibition of cytokine expression and induction of histamine release.
Anandamide inhibits the DOI-induced head-twitch response in mice
- Biology, MedicinePsychopharmacology
- 2004
Findings suggest that the endocannabinoid anandamide may inhibit 5-HT2A receptor-mediated function via the arachidonic acid cascade, but not via a direct interaction with the CB1 cannabinoid receptor, and that the mechanism of its action is clearly different from that of THC.
Endocannabinoid System Modulates Relapse to Methamphetamine Seeking: Possible Mediation by the Arachidonic Acid Cascade
- Biology, PsychologyNeuropsychopharmacology
- 2004
The results suggest that endocannabinoid-activating substances as well as cyclooxygenase inhibitors may be promising as antirelapse agents and extend the current view on the treatment of drug dependence.
Prostaglandin E2 attenuates SR141716A-precipitated withdrawal in tetrahydrocannabinol-dependent mice
- Biology, MedicineBrain Research
- 2003
Indomethacin Enhances Type 1 Cannabinoid Receptor Signaling
- Biology, MedicineFront. Mol. Neurosci.
- 2019
Data support the hypothesis that indomethacin acted as a positive allosteric modulator of hCB1R and may lead to the development of novel compounds designed for greater CB1R or COX selectivity and compounds designed to modulate both the prostaglandin and endocannabinoid systems.
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