Behavioral sensitization to kainic acid and quisqualic acid in mice: comparison to NMDA and substance P responses.

@article{Sun1991BehavioralST,
  title={Behavioral sensitization to kainic acid and quisqualic acid in mice: comparison to NMDA and substance P responses.},
  author={Xian Feng Sun and Alice A. Larson},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1991},
  volume={11 10},
  pages={3111-23}
}
Substance P (SP) and the excitatory amino acid (EAA) agonists NMDA, kainic acid (KA), or quisqualic acid (Quis) each produce a transient, caudally directed biting and scratching response (CBS) in mice after their intrathecal injection. We have previously shown that repeated injections of SP result in a decrease in the intensity of CBS, or desensitization. The goals of the present study were (1) to determine whether desensitization also develops to the CBS behavior produced by EAAs in the spinal… CONTINUE READING