Behavioral responses to hypoxia in Drosophila larvae are mediated by atypical soluble guanylyl cyclases.

@article{VermehrenSchmaedick2010BehavioralRT,
  title={Behavioral responses to hypoxia in Drosophila larvae are mediated by atypical soluble guanylyl cyclases.},
  author={Anke Vermehren-Schmaedick and Joshua A. Ainsley and Wayne A. Johnson and Shireen A. Davies and David B Morton},
  journal={Genetics},
  year={2010},
  volume={186 1},
  pages={183-96}
}
The three Drosophila atypical soluble guanylyl cyclases, Gyc-89Da, Gyc-89Db, and Gyc-88E, have been proposed to act as oxygen detectors mediating behavioral responses to hypoxia. Drosophila larvae mutant in any of these subunits were defective in their hypoxia escape response-a rapid cessation of feeding and withdrawal from their food. This response required cGMP and the cyclic nucleotide-gated ion channel, cng, but did not appear to be dependent on either of the cGMP-dependent protein kinases… CONTINUE READING
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