Behavioral responses to cocaine and amphetamine administration in mice lacking the dopamine D1 receptor.

@article{Xu2000BehavioralRT,
  title={Behavioral responses to cocaine and amphetamine administration in mice lacking the dopamine D1 receptor.},
  author={Ming Xu and Y Guo and Charles V Vorhees and Jianxiong Zhang},
  journal={Brain research},
  year={2000},
  volume={852 1},
  pages={198-207}
}
Cocaine and amphetamine can induce both short-term and long-term behavioral changes in rodents. The major target for these psychostimulants is thought to be the brain dopamine system. To determine whether the dopamine D1 receptor plays a crucial role in the behavioral effects of psychostimulants, we tested both the locomotor and stereotyped behaviors in D1 receptor mutant and wild-type control mice after cocaine and amphetamine treatments. We found that the overall locomotor responses of D1… CONTINUE READING

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