Behavioral responses of epidermal Langerhans cells in situ to local pathological stimuli.

@article{Nishibu2006BehavioralRO,
  title={Behavioral responses of epidermal Langerhans cells in situ to local pathological stimuli.},
  author={Akiko Nishibu and Brant Russell Ward and James V. Jester and Hidde L. Ploegh and Marianne Boes and Akihiko Takashima},
  journal={The Journal of investigative dermatology},
  year={2006},
  volume={126 4},
  pages={
          787-96
        }
}
Pathological stimuli provoke coordinated changes in gene expression, surface phenotype, and function of dendritic cells (DCs), thereby facilitating the induction of adaptive immune responses. This concept of DC maturation was established mainly by studying epidermal Langerhans cells (LCs), a prototypic immature DC subset at the environmental interface. Taking advantage of I-Abeta-enhanced green fluorescent protein (EGFP) knock-in mice in which LCs can be visualized in intact skin, we recorded… CONTINUE READING
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