Behavioral responses of Vipr2-/- mice to light.

  title={Behavioral responses of Vipr2-/- mice to light.},
  author={Alun Hughes and Hugh D. Piggins},
  journal={Journal of biological rhythms},
  volume={23 3},
Vasoactive intestinal polypeptide and its receptor, VPAC2, play important roles in the functioning of the dominant circadian pacemaker, located in the hypothalamic suprachiasmatic nuclei (SCN). Mice lacking VPAC2 receptors (Vipr2-/-) show altered circadian rhythms and impaired synchronization to environmental lighting cues. However, light can increase phosphoprotein and immediate early gene expression in the Vipr2-/- SCN demonstrating that the circadian clock is readily responsive to light in… CONTINUE READING


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