Behavioral phenotyping of transgenic and knockout mice: experimental design and evaluation of general health, sensory functions, motor abilities, and specific behavioral tests 1 Published on the World Wide Web on 2 December 1998. 1

  title={Behavioral phenotyping of transgenic and knockout mice: experimental design and evaluation of general health, sensory functions, motor abilities, and specific behavioral tests
 Published on the World Wide Web on 2 December 1998.
  author={Jacqueline N. Crawley},
  journal={Brain Research},
  • J. Crawley
  • Published 1 July 1999
  • Psychology, Biology
  • Brain Research

Behavioral phenotyping of transgenic and knockout mice: practical concerns and potential pitfalls.

Strategies aimed at minimizing environmental variability and contributions of background genes will enhance the robustness of mouse behavioral phenotyping assays.

Behavioral phenotyping of mice in pharmacological and toxicological research.

  • T. KarlR. PabstS. von Hörsten
  • Psychology, Biology
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie
  • 2003
A general approach is designed to describe a general approach, which increases reliability of behavioral screening, and provides an overview on a selection of specific procedures suitable for but not limited to behavioral screening in pharmacology and toxicology.

Mouse behavioral tasks relevant to autism: Phenotypes of 10 inbred strains

Reliability, robustness, and reproducibility in mouse behavioral phenotyping: a cross-laboratory study.

The EUMORPHIA SOPs described here are an important start-point for the ongoing development of increasingly robust phenotyping platforms and their application in large-scale, multicentre mouse phenotypes programs.

A Simple and Fast Battery Test for Phenotypic Characterization of Mice.

The battery test proposed is to settle a specific methodology to characterize the phenotype of neurological disease models in mutant or genetically modified mice, which is simple and efficient in order to analyze several parameters, including general activity, sensory nervous system, sensorimotor system, central nervous system and autonomous nervous system.

Behavioral profiles of inbred strains on novel olfactory, spatial and emotional tests for reference memory in mice

Comparison of strains for open field exploratory activity and anxiety‐like behavior suggests that poor Barnes maze performance reflects low exploratory behavior, rather than a true spatial memory deficit, in 129S6 mice.

Behavioral characterization of dopamine D5 receptor null mutant mice.

The results suggest that the D5 receptor is not essential for many dopamine-mediated behaviors but may contribute to the pharmacological activation of dopaminergic pathways relevant to exploratory locomotion, startle, and prepulse inhibition.

Developing standardized behavioral tests for knockout and mutant mice.

Test batteries for examining sensory and motor behavior, species-typical behavior, learning and memory, and development and aging in transgenic mice are reviewed.



Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies

Strain distributions are described for open field activity, learning and memory tasks, aggression, sexual and parental behaviors, acoustic startle and prepulse inhibition, and the behavioral actions of ethanol, nicotine, cocaine, opiates, antipsychotics, and anxiolytics.

Behavior in Mice with Targeted Disruption of Single Genes

A Proposed Test Battery and Constellations of Specific Behavioral Paradigms to Investigate the Behavioral Phenotypes of Transgenic and Knockout Mice

A series of neurological and neuropsychological tests which are effectively used as a first screen for behavioral abnormalities in mutant mice are described, and a series of specific behavioral paradigms, clustered by category, are described.

Genetic analysis of anxiety-related behaviors and responses to benzodiazepine-related drugs in AXB and BXA recombinant inbred mouse strains

The strain distribution patterns and estimates of the minimal number of loci obtained for each trait suggest that multiple chromosomal loci contribute to differences in anxiety-related behavioral phenotypes and the behavioral responses to diazepam and β-CCM between C57BL/6J and A/J mice.

Cocaine Reward and Locomotor Activity in C57BL/6J and 129/SvJ Inbred Mice and Their F1 Cross

  • L. Miner
  • Biology, Psychology
    Pharmacology Biochemistry and Behavior
  • 1997

Learning impairment in transgenic mice with central overexpression of corticotropin-releasing factor

Alpha7 nicotinic receptor subunits are not necessary for hippocampal-dependent learning or sensorimotor gating: a behavioral characterization of Acra7-deficient mice.

The results of this study show that the absence of alpha7 nAChRs has little impact on normal, base-line behavioral responses, and future studies will examine the contribution ofalpha7nAChR to the enhancement of learning and sensorimotor gating following nicotine treatments.

Hyperactivity and learning deficits in transgenic mice bearing a human mutant thyroid hormone beta1 receptor gene.

Results indicate that transgenic mice bearing a mutant human TRbeta gene demonstrate several behavioral characteristics of ADHD and may serve a valuable heuristic role in elucidating possible candidate genes in converging pathways for other causes of ADHD.

Characterization of benzodiazepine-sensitive behaviors in the A/J and C57BL/6J inbred strains of mice

C57BL/6J and A/J mice should be useful parental strains in recombinant inbred lines for investigating the genetic determinants of benzodiazepine-sensitive behaviors and sensitivity to drugs acting on the GABAA/benzodiazepines receptor complex.