Behavioral phenotypic variation in autism multiplex families: evidence for a continuous severity gradient.

@article{Spiker2002BehavioralPV,
  title={Behavioral phenotypic variation in autism multiplex families: evidence for a continuous severity gradient.},
  author={Donna Spiker and Linda J Lotspeich and Sue Dimiceli and Richard M. Myers and Neil J. Risch},
  journal={American journal of medical genetics},
  year={2002},
  volume={114 2},
  pages={129-36}
}
Recent genetic investigations of autism have studied multiplex families, typically including families with multiple siblings who meet criteria for a diagnosis of autism. However, little is known about the specific behavioral characteristics of siblings with autism in these multiplex families. We investigated the behavioral phenotypic variability and similarity of 351 siblings with autism in 171 multiplex families using cluster analysis and correlations. The results of cluster analyses showed… CONTINUE READING

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