Behavioral patterns under cholinergic control during development: lessons learned from the selective immunotoxin 192 IgG saporin.

  • Laura Ricceri
  • Published 2003 in Neuroscience and biobehavioral reviews


The immunotoxin 192 IgG saporin (192 IgG-sap) offers a valuable tool to investigate the role of the developing basal forebrain cholinergic system in modulating behavioral functions in developing, as well as adult rats. After neonatal 192 IgG-sap lesions, rats display reduced ultrasonic vocalizations as neonates, deficits in passive avoidance learning as… (More)


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