Behavioral-neuroendocrine-immunologic interactions in myocardial infarction.

  title={Behavioral-neuroendocrine-immunologic interactions in myocardial infarction.},
  author={Karl Goodkin and A W Appels},
  journal={Medical hypotheses},
  volume={48 3},
An enduring state of exhaustion as opposed to chronic hostility-a long-term risk factor-has been found to be a more proximal precursor of myocardial infarction. The strength of the association with exhaustion suggests that this behavioral factor reflects not only a breakdown in adaptation to chronic stressors but also the disease process itself. Recent research on the pathogenesis of myocardial infarction lends credence to a role for immunological factors. herein, we outline a two-stage… CONTINUE READING