Behavioral motor dysfunction in Kv3-type potassium channel-deficient mice.

  title={Behavioral motor dysfunction in Kv3-type potassium channel-deficient mice.},
  author={Rolf H. Joho and Conestoga Street and Shinichi Matsushita and Thomas Kn{\"o}pfel},
  journal={Genes, brain, and behavior},
  volume={5 6},
The voltage-gated potassium channels Kv3.1 and Kv3.3 are expressed in several distinct neuronal subpopulations in brain areas known to be involved in motor control such as cortex, basal ganglia and cerebellum. Depending on the lack of Kv3.1 or Kv3.3 channel subunits, mutant mice show different Kv3-null allele-dependent behavioral alterations that include constitutive hyperactivity, sleep loss, impaired motor performance and, in the case of the Kv3.1/Kv3.3 double mutant, also severe ataxia… CONTINUE READING
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