Behavioral insights from mouse models of forebrain--and amygdala-specific glucocorticoid receptor genetic disruption.

@article{Arnett2011BehavioralIF,
  title={Behavioral insights from mouse models of forebrain--and amygdala-specific glucocorticoid receptor genetic disruption.},
  author={Melinda G Arnett and Benedict J. Kolber and Maureen P. Boyle and Louis J. Muglia},
  journal={Molecular and cellular endocrinology},
  year={2011},
  volume={336 1-2},
  pages={2-5}
}
Genetic modulation of glucocorticoid receptor (GR) function in the brain using transgenic and gene knockout mice has yielded important insights into many aspects of GR effects on behavior and neuroendocrine responses, but significant limitations regarding interpretation of region-specific and temporal requirements remain. Here, we summarize the behavioral phenotype associated with two knockout mouse models to define the role of GRs specifically within the forebrain and amygdala. We report that… CONTINUE READING