Behavioral flexibility and response selection are impaired after limited exposure to oxycodone.

@article{SeipCammack2014BehavioralFA,
  title={Behavioral flexibility and response selection are impaired after limited exposure to oxycodone.},
  author={Katharine M. Seip-Cammack and Matthew L. Shapiro},
  journal={Learning \& memory},
  year={2014},
  volume={21 12},
  pages={
          686-95
        }
}
Behavioral flexibility allows individuals to adapt to situations in which rewards and goals change. Potentially addictive drugs may impair flexible decision-making by altering brain mechanisms that compute reward expectancies, thereby facilitating maladaptive drug use. To investigate this hypothesis, we tested the effects of oxycodone exposure on rats in two complementary learning and memory tasks that engage distinct learning strategies and neural circuits. Rats were trained first in either a… 

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This work was supported by the National Institutes of Health [grant number P20 GM113109-01A1].
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