Behavioral effects of the CRF1 receptor antagonist R121919 in rats selectively bred for high and low activity in the swim test.

Abstract

This study assessed effects of a CRF(1) receptor antagonist, R121919, on the behavior of rats that have been selectively bred to exhibit very high or very low activity in a swim test. Following treatment with R121919 (10 mg/kg, s.c.) or vehicle, several types of behavior were examined including: (1) spontaneous ambulatory activity in a novel environment, (2… (More)
DOI: 10.1016/j.psyneuen.2008.05.003

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@article{Gutman2008BehavioralEO, title={Behavioral effects of the CRF1 receptor antagonist R121919 in rats selectively bred for high and low activity in the swim test.}, author={David A. Gutman and Megan J. Coyer and Katherine A. Boss-Williams and Michael J. Owens and Charles B. Nemeroff and Jay Michael Weiss}, journal={Psychoneuroendocrinology}, year={2008}, volume={33 8}, pages={1093-101} }