Behavioral effects of saredutant, a tachykinin NK2 receptor antagonist, in experimental models of mood disorders under basal and stress-related conditions.

@article{Micale2008BehavioralEO,
  title={Behavioral effects of saredutant, a tachykinin NK2 receptor antagonist, in experimental models of mood disorders under basal and stress-related conditions.},
  author={Vincenzo Micale and Alessandra Tamburella and Gian Marco Leggio and Carmen Mazzola and Valentina Li Volsi and Filippo Drago},
  journal={Pharmacology, biochemistry, and behavior},
  year={2008},
  volume={90 3},
  pages={463-9}
}
The present study was made to investigate the role of tachykinin NK2 receptors in the expression of stress-related behaviors in animals. Under basal conditions, intraperitoneal (i.p.) administration of the selective tachykinin NK2 receptor antagonist, saredutant (1 and 3 mg/kg) or diazepam (1 mg/kg) exerted anxiolytic-like effects in rodents, as they reduced grooming score of Wistar male rats tested in the novelty-induced grooming sampling test (NGT) and increased percentage of time and entries… CONTINUE READING

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