Behavioral effects of rolipram and structurally related compounds in mice: behavioral sedation of cAMP phosphodiesterase inhibitors.

@article{Griebel1991BehavioralEO,
  title={Behavioral effects of rolipram and structurally related compounds in mice: behavioral sedation of cAMP phosphodiesterase inhibitors.},
  author={Guy Griebel and Ren{\'e} Misslin and E. E. Vogel and Jean Jacques Bourguignon},
  journal={Pharmacology, biochemistry, and behavior},
  year={1991},
  volume={39 2},
  pages={321-3}
}
The behavioral effects of specific cAMP phosphodiesterase inhibitors (PDE-I) such as rolipram and structurally related compounds were investigated in mice. Selected PDE-I induced a potent dose-dependent decrease in locomotion and in rearing of mice confronted with a free exploratory procedure, these effects being considered as a behavioral sedation. However, in the light/dark choice test especially conceived to reveal disinhibitory and/or anxiolytic action, they did not show obvious effects… CONTINUE READING

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