Behavioral effects of peripheral corticotropin-releasing factor during maternal separation may be mediated by proinflammatory activity.

@article{Hennessy2011BehavioralEO,
  title={Behavioral effects of peripheral corticotropin-releasing factor during maternal separation may be mediated by proinflammatory activity.},
  author={Michael B. Hennessy and Christopher Fitch and Sarah L. Jacobs and Terrence Deak and Patricia A Schiml},
  journal={Psychoneuroendocrinology},
  year={2011},
  volume={36 7},
  pages={996-1004}
}
When guinea pig pups are separated from their mothers in a novel environment, an initial period of active behavior (vocalizing, locomotor activity) wanes after an hour or so and is replaced by a second, passive stage characterized by a crouched stance, closed eyes, and extensive piloerection. If pups are given a peripheral injection of 7-14μg of corticotropin-releasing factor (CRF) prior to testing, the passive behaviors occur immediately upon separation. We found that intracerebroventricular… CONTINUE READING

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