Behavioral effects of four novel synthetic cathinone analogs in rodents

@article{Gatch2020BehavioralEO,
  title={Behavioral effects of four novel synthetic cathinone analogs in rodents},
  author={Michael B. Gatch and Ritu A Shetty and Nathalie Sumien and Michael J Forster},
  journal={Addiction Biology},
  year={2020},
  volume={26}
}
A new generation of novel cathinone compounds has been developed as stimulant substitutes to avoid drug control laws and detection of use by blood tests. Dipentylone, N‐ethylhexedrone, 4‐chloroethcathinone (4‐CEC), and 4′‐methyl‐α‐pyrrolidinohexiophenone (MPHP) were tested for in vivo psychostimulant‐like effects to assess their abuse liability. Locomotor activity was assessed in an open‐field assay using Swiss–Webster mice to screen for locomotor stimulant effects and to identify behaviorally… 
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References

SHOWING 1-10 OF 50 REFERENCES
Discriminative and locomotor effects of five synthetic cathinones in rats and mice
TLDR
All of the tested compounds produce discriminative stimulus effects similar to either those of cocaine, methamphetamine, or both, which suggests that these compounds are likely to have similar abuse liability to cocaine and/or methamphetamine.
Locomotor activity and discriminative stimulus effects of a novel series of synthetic cathinone analogs in mice and rats
TLDR
Initial evidence is provided that these structurally similar, emerging novel psychoactive substances demonstrate potential for abuse and may be utilized for their stimulant-like effects, given their ability to stimulate locomotor activity and their substitution for the discriminative stimulus effects of the classical psychostimulants cocaine and or methamphetamine.
Cocaine‐like discriminative stimulus effects of alpha‐pyrrolidinovalerophenone, methcathinone and their 3,4‐methylenedioxy or 4‐methyl analogs in rhesus monkeys
TLDR
Results suggest different structural requirements for cocaine‐like discriminative stimulus effects of monoamine transporter inhibitor and substrate synthetic cathinone analogs, and suggest hydrophobicity may be an important determinant for limiting monoamines transporter substrate abuse‐related behavioral effects.
Locomotor stimulant and discriminative stimulus effects of ‘bath salt’ cathinones
TLDR
Several commonly marketed cathinones produce discriminative stimulus effects comparable with those of cocaine and methamphetamine, which suggests that these compounds are likely to have similar abuse liabilities.
Behavioral evidence for the abuse potential of the novel synthetic cathinone alpha-pyrrolidinopentiothiophenone (PVT) in rodents
TLDR
The results indicate that alpha-PVT has rewarding and reinforcing effects and shares the interoceptive effects of cocaine and methamphetamine, which suggests possible abuse liability in humans.
Locomotor and reinforcing effects of pentedrone, pentylone and methylone in rats
TLDR
The inference that second generation cathinones pentylone and pentedrone have abuse liability greater than that of methylone is supported.
Discriminative stimulus and locomotor effects of para-substituted and benzofuran analogs of amphetamine.
Effects of D1 and D2 receptor antagonists on the discriminative stimulus effects of methylendioxypyrovalerone and mephedrone in male Sprague-Dawley rats trained to discriminate D-amphetamine
TLDR
Preliminary findings indicate that MDPV and MEPH produce interoceptive stimuli that are similar to those produced by AMPH and that D1 and D2 dopamine receptors contribute to these effects.
Cocaine-like discriminative stimulus effects of amphetamine, cathinone, methamphetamine, and their 3,4-methylenedioxy analogs in male rhesus monkeys
TLDR
The presence of an N-methyl group blunted both the potency and the efficacy shift of the 3,4-methylenedioxy addition for both amphetamine and cathinone analogs.
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