Behavioral effects of four novel synthetic cathinone analogs in rodents

  title={Behavioral effects of four novel synthetic cathinone analogs in rodents},
  author={Michael B. Gatch and Ritu A Shetty and Nathalie Sumien and Michael J Forster},
  journal={Addiction Biology},
A new generation of novel cathinone compounds has been developed as stimulant substitutes to avoid drug control laws and detection of use by blood tests. Dipentylone, N‐ethylhexedrone, 4‐chloroethcathinone (4‐CEC), and 4′‐methyl‐α‐pyrrolidinohexiophenone (MPHP) were tested for in vivo psychostimulant‐like effects to assess their abuse liability. Locomotor activity was assessed in an open‐field assay using Swiss–Webster mice to screen for locomotor stimulant effects and to identify behaviorally… 

Human Neuronal Cell Lines as An In Vitro Toxicological Tool for the Evaluation of Novel Psychoactive Substances

The present in vitro study investigated the possible mechanisms of toxicity of two emerging NPS and evaluated the toxicity of fentanyl, as a reference compound for this group of frequently abused substances.

A review of synthetic cathinones emerging in recent years (2019–2022)

Most of the newly developed synthetic cathinones can be seen as analogs and replacements for once-popular compounds that have been declining in popularity as a result of legislative efforts.

Expression of stable and reliable preference and aversion phenotypes following place conditioning with psychostimulants.

These studies suggest that taking phenotype into consideration when designing place conditioning studies will improve their application as a preclinical tool in addiction biology and drug discovery.



Discriminative and locomotor effects of five synthetic cathinones in rats and mice

All of the tested compounds produce discriminative stimulus effects similar to either those of cocaine, methamphetamine, or both, which suggests that these compounds are likely to have similar abuse liability to cocaine and/or methamphetamine.

Comparative Behavioral Pharmacology of Three Pyrrolidine-Containing Synthetic Cathinone Derivatives

It is suggested that α-PBP andα-PVP are likely to be recreationally used and have potential for addiction and abuse, but 4ʹ-MePPP may not.

Locomotor activity and discriminative stimulus effects of a novel series of synthetic cathinone analogs in mice and rats

Initial evidence is provided that these structurally similar, emerging novel psychoactive substances demonstrate potential for abuse and may be utilized for their stimulant-like effects, given their ability to stimulate locomotor activity and their substitution for the discriminative stimulus effects of the classical psychostimulants cocaine and or methamphetamine.

Cocaine‐like discriminative stimulus effects of alpha‐pyrrolidinovalerophenone, methcathinone and their 3,4‐methylenedioxy or 4‐methyl analogs in rhesus monkeys

Results suggest different structural requirements for cocaine‐like discriminative stimulus effects of monoamine transporter inhibitor and substrate synthetic cathinone analogs, and suggest hydrophobicity may be an important determinant for limiting monoamines transporter substrate abuse‐related behavioral effects.

Locomotor stimulant and discriminative stimulus effects of ‘bath salt’ cathinones

Several commonly marketed cathinones produce discriminative stimulus effects comparable with those of cocaine and methamphetamine, which suggests that these compounds are likely to have similar abuse liabilities.

Behavioral evidence for the abuse potential of the novel synthetic cathinone alpha-pyrrolidinopentiothiophenone (PVT) in rodents

The results indicate that alpha-PVT has rewarding and reinforcing effects and shares the interoceptive effects of cocaine and methamphetamine, which suggests possible abuse liability in humans.

Cocaine-Like Discriminative Stimulus Effects of Mephedrone and Naphyrone in Mice

Assessment of cocaine-like interoceptive effects of synthetic cathinone analogues functioning as passive monoamine reuptake inhibitors (naphyrone) or as releasers (mephedrone) in mice suggests that synthetic cath inones likely elicit psychostimulant-like abuse-related effects.