Behavioral effects of estrogen receptor gene disruption in male mice.

  title={Behavioral effects of estrogen receptor gene disruption in male mice.},
  author={Sonoko Ogawa and Dennis B. Lubahn and Kenneth S. Korach and Donald W. Pfaff},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={94 4},
Gonadal steroid hormones regulate sexually dimorphic development of brain functions and behaviors. Their nuclear receptors offer the opportunity to relate molecular events in neurons to simple instinctive mammalian behaviors. We have determined the role of estrogen receptor (ER) activation by endogenous estrogen in the development of male-typical behaviors by the use of transgenic estrogen-receptor-deficient (ERKO) mice. Surprisingly, in spite of the fact that they are infertile, ERKO mice… CONTINUE READING


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