Behavioral effects of cocaine on a transgenic mouse model of cortical-limbic compulsion.

@article{Campbell1999BehavioralEO,
  title={Behavioral effects of cocaine on a transgenic mouse model of cortical-limbic compulsion.},
  author={Kathryn M Campbell and Matthew J. McGrath and Frank H. Burton},
  journal={Brain research},
  year={1999},
  volume={833 2},
  pages={216-24}
}
We previously created a transgenic mouse model of cortical-limbic induced compulsions in which dopamine D1 receptor-expressing (D1+) neurons in restricted regional subsets of the cortex and amygdala express a neuropotentiating cholera toxin (CT) transgene. These 'D1CT' mice engage in complex behavioral abnormalities uniquely resembling human compulsions, such as non-aggressive biting of cagemates during grooming, repeated leaping and episodes of perseverance of any and all normal behaviors… CONTINUE READING

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