Behavioral effects of 2,5-dimethoxy-4-methylamphetamine (DOM) in rats and mice.

  title={Behavioral effects of 2,5-dimethoxy-4-methylamphetamine (DOM) in rats and mice.},
  author={Takashi Yamamoto and Showa Ueki},
  journal={European journal of pharmacology},
  volume={32 02},
The characteristics of the behavioral effects of 2,5-dimethoxy-4-methylamphetamine (DOM or STP) were compared with those of mescaline and methamphetamine in rats and mice. DOM significantly increased locomotor activity in an open-field situation at 0.5-1.0 mg/kg i.p., but at doses above 5 mg/kg i.p. caused biphasic changes, i.e. an initial decrease followed by an increase in motility and exploratory behavior. This hyperactivity was not accompanied by simultaneous increase in rearing. Besides… CONTINUE READING


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