Behavioral effects and pharmacokinetics of propofol in rats selected for differential ethanol sensitivity.

@article{Liu1995BehavioralEA,
  title={Behavioral effects and pharmacokinetics of propofol in rats selected for differential ethanol sensitivity.},
  author={Y. Liu and T. Fay and R. Deitrich},
  journal={Alcoholism, clinical and experimental research},
  year={1995},
  volume={19 4},
  pages={
          874-8
        }
}
High- and low-alcohol sensitivity (HAS and LAS) rats have been selected for their differences in ethanol-induced sleep time. The rats also differ in sensitivity to pentobarbital, halothane, isoflurane, and enflurane. To determine if this sensitivity extended to propofol, the anesthetic requirements were measured. In this study, the sleep time and the tissue levels of propofol at awakening, as well as the pharmacokinetics, were evaluated. Propofol was administered intravenously. For one group of… Expand
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