Behavioral effects and pharmacokinetics of propofol in rats selected for differential ethanol sensitivity.

  title={Behavioral effects and pharmacokinetics of propofol in rats selected for differential ethanol sensitivity.},
  author={Y. Liu and T. Fay and R. Deitrich},
  journal={Alcoholism, clinical and experimental research},
  volume={19 4},
High- and low-alcohol sensitivity (HAS and LAS) rats have been selected for their differences in ethanol-induced sleep time. The rats also differ in sensitivity to pentobarbital, halothane, isoflurane, and enflurane. To determine if this sensitivity extended to propofol, the anesthetic requirements were measured. In this study, the sleep time and the tissue levels of propofol at awakening, as well as the pharmacokinetics, were evaluated. Propofol was administered intravenously. For one group of… Expand
Pharmacokinetics of Propofol Administered by Target-controlled Infusion to Alcoholic Patients
Propofol pharmacokinetics are markedly different during anesthesia and surgery or after opening eyes in the recovery period, compared with control patients, which indicates that chronic alcoholism induces only mild changes in the Pharmacokinetics of propofol. Expand
Role of GABA in the Actions of Ethanol in Rats Selectively Bred for Ethanol Sensitivity
These lines of rats have very marked line differences in GABA-mediated events, and these are correlated with the sedative effects of ethanol, which should be useful in dissecting the actions of ethanol at the GABA(A) receptor. Expand
Rats show unimpaired learning within minutes after recovery from single bolus propofol anesthesia
The ability to learn recovers rapidly after propofol anesthesia induced by a single intravenous bolus dose, and produced the same resistance to the disruptive effects of scopolamine as did training in rats that were not anesthetized. Expand
Genetic models in the study of anesthetic drug action.
This chapter reviews the use of genetic models in the study of anesthetic drug action and discusses studies employing lines derived from spontaneous and induced mutagenic processes, selectively bred lines, and inbred lines possessing inherent differential drug sensitivities. Expand


Effect of pentobarbital and gaseous anesthetics on rats selectively bred for ethanol sensitivity
The results show that, by the use of these anesthetics in combination with selectively bred rodent lines, many new opportunities for dissecting the molecular mechanisms of anesthetic agents present themselves. Expand
Differential effects of central nervous system depressants in long-sleep and short-sleep mice.
The relative sleep time response of long- sleep (LS) and short-sleep (SS) mice was determined after the i.p. injection of varying doses of several anesthetic agents that vary in lipid solubility, indicating that the LS and SS mice do not differ only in response to alcohols, rather, they differ in sensitivity to agents that have lipidsolubilities which resemble that of ethanol. Expand
Thiopental, phenobarbital, and chlordiazepoxide induce the same differences in narcotic reaction as ethanol in long-sleep and short-sleep selectively-bred mice
Findings with regard to the LS and SS lines suggest that the differences in sedative response to ethanol, as well as some barbiturates and benzodiazepines, may be mediated, in part, by a common mechanism. Expand
HAS and LAS rats respond differentially to behavioral effects of ethanol, pentobarbital, chlorpromazine and chlordiazepoxide
  • E. C. Krimmer
  • Medicine, Chemistry
  • Pharmacology Biochemistry and Behavior
  • 1991
The drug discrimination paradigm (DD) was used to evaluate differences in performance of rats selectively bred for differential sensitivity to the hypnotic effects of ethanol, indicating a dissociation of rate depressant effects and discriminative performance following ethanol. Expand
Development of central nervous system sensitivity to ethanol and pentobarbital in short- and long-sleep mice.
Short-sleep mouse pups ranging in age from days 9 to 12 are more sensitive to pentobarbital than are long-sleep mice, and the system responsible might be the gamma-amino-butyric acid-mediated chloride flux which has also been shown to develop tolerance within 5 min after ethanol injection. Expand
Differential response to flurazepam in long-sleep and short-sleep mice
It is demonstrated that LS and SS mice differ in response to flurazepam, but the nature of the difference depends on the type of response measured and the dose of flurzepam employed. Expand
Effect of hypnotics on mice genetically selected for sensitivity to ethanol
The data indicate that while the SS and LS lines of mice differ in central nervous system sensitivity to ethanol, methanol, butanol and t-butanol it is implied that they do no differ inCentral nervous systemensitivity to other hypnotic agents tested. Expand
The effect of halothane on mice selectively bred for differential sensitivity to alcohol
It is concluded that the mechanism of action of ethanol and halothane differ in a significant way from each other. Expand
The General Anesthetic Propofol Enhances the Function of γ‐Aminobutyric Acid‐Coupled Chloride Channel in the Rat Cerebral Cortex
Data strongly suggest that propofol, like other anesthetics and positive modulators of GABAergic transmission, might exert its pharmacological effects by enhancing the function of the GABA‐activated chloride channel. Expand
Relationship between acute ethanol-related responses in long-sleep and short-sleep mice.
Since the two lines were selected only for a sleep time difference, a differential sensitivity to other consequences of acute ethanol exposure, such as the lethal dose, would not be expected unless the effects shared a common genetic mechanism of action with ethanol sleep time. Expand