Behavioral effects and anatomic correlates after brain injury: a progesterone dose-response study.

@article{Goss2003BehavioralEA,
  title={Behavioral effects and anatomic correlates after brain injury: a progesterone dose-response study.},
  author={Cynthia W Goss and Stuart W. Hoffman and Donald G. Stein},
  journal={Pharmacology, biochemistry, and behavior},
  year={2003},
  volume={76 2},
  pages={231-42}
}
Evidence suggests that progesterone enhances functional recovery in rats after medial frontal cortical contusions; however, a high dose of progesterone exacerbates tissue loss in a stroke model when administered chronically (7-10 days) prior to injury [Stroke 31 (2000) 1173)]. This study attempts to determine progesterone's dose-response effects on behavioral performance and GABA-A receptor expression following a cortical contusion. Male rats received injections of 0, 8, 16, or 32 mg/kg… CONTINUE READING
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