Behavioral disturbances in transgenic mice overexpressing the V717F beta-amyloid precursor protein.

@article{Dodart1999BehavioralDI,
  title={Behavioral disturbances in transgenic mice overexpressing the V717F beta-amyloid precursor protein.},
  author={Jean Cosme Dodart and Hamid Meziane and Chantal Mathis and Kelly R. Bales and Steven M Paul and Arielle Ungerer},
  journal={Behavioral neuroscience},
  year={1999},
  volume={113 5},
  pages={982-90}
}
PDAPP transgenic mice have been shown to develop age dependently much of the cerebral histopathology associated with Alzheimer's disease. PDAPP mice (3-10 months old) were tested in a battery of memory tasks to determine whether they develop memory-behavioral deficits and whether these deficits occur before or after amyloid deposition. PDAPP mice manifest robust impairments in a radial-maze spatial discrimination task at all ages tested. Mild deficits were observed in a barpress learning task… CONTINUE READING

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