Behavioral disinhibition induced by tryptophan depletion in nonalcoholic young men with multigenerational family histories of paternal alcoholism.

@article{Lemarquand1999BehavioralDI,
  title={Behavioral disinhibition induced by tryptophan depletion in nonalcoholic young men with multigenerational family histories of paternal alcoholism.},
  author={D Lemarquand and C. Benkelfat and R O Pihl and Roberta M Palmour and Simon N. Young},
  journal={The American journal of psychiatry},
  year={1999},
  volume={156 11},
  pages={1771-9}
}
OBJECTIVE A deficit in serotonergic neurotransmission has been linked to impulsive behavior, as well as to disorders characterized by disinhibition. The present study tested the hypothesis that young men at high risk for alcoholism demonstrate greater behavioral disinhibition after acute dietary depletion of tryptophan, the amino acid precursor of serotonin. METHOD A double-blind, placebo-comparison, between-subjects study design was used. Nonalcoholic young men with a multigenerational… CONTINUE READING