Behavioral differences between subgroups of rats with high and low threshold to clonic convulsions induced by DMCM, a benzodiazepine inverse agonist

@article{Cont2005BehavioralDB,
  title={Behavioral differences between subgroups of rats with high and low threshold to clonic convulsions induced by DMCM, a benzodiazepine inverse agonist},
  author={M. B. Cont{\'o} and Jos{\'e} Gilberto Barbosa de Carvalho and M. A. Benedito},
  journal={Pharmacology Biochemistry and Behavior},
  year={2005},
  volume={82},
  pages={417-426}
}
In epileptic patients, there is a high incidence of psychiatric comorbidities, such as anxiety. Gamma-aminobutyric acid (GABA) ionotropic receptor GABA(A)/benzodiazepine allosteric site is involved in both epilepsy and anxiety. This involvement is based on the fact that benzodiazepine allosteric site agonists are anticonvulsant and anxiolytic drugs; on the other hand, benzodiazepine inverse agonists are potent convulsant and anxiogenic drugs. The aim of this work was to determine if subgroups… Expand
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