Behavioral deficits induced by low doses of apomorphine in rats: Evidence for a motivational and cognitive dysfunction which discriminates among neuroleptic drugs

@article{Carnoy1986BehavioralDI,
  title={Behavioral deficits induced by low doses of apomorphine in rats: Evidence for a motivational and cognitive dysfunction which discriminates among neuroleptic drugs},
  author={Pascale Carnoy and Sophie Ravard and B. Wemerman and Ph. Soubri{\'e} and Pierre Simon},
  journal={Pharmacology Biochemistry and Behavior},
  year={1986},
  volume={25},
  pages={503-509}
}
In order to further assess the alterations (motor, motivational or cognitive) that might underlie animal behavioral deficits associated with a reduced dopamine transmission, the effects of apomorphine at doses thought to stimulate dopaminergic autoreceptors were studied on rat operant behavior. Apomorphine (30 micrograms/kg SC) decreased the number of food rewards obtained, when rats trained on a continuous reinforced schedule were shifted to schedules of fixed ratio higher than 2:FR3, FR4, and… CONTINUE READING
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