Behavioral correlates of hippocampal type 2 theta in the rat

  title={Behavioral correlates of hippocampal type 2 theta in the rat},
  author={Robert Sainsbury and Arnold J. Heynen and Christopher P. E. Montoya},
  journal={Physiology \& Behavior},
Previous research has indicated that there are two types of theta activity which can be recorded from the hippocampus in most rodents. One type (type 1) of theta is correlated with voluntary movements while the second (type 2) occurs during immobility. A third waveform termed LIA (Large Amplitude Irregular Activity) occurs during more automatic behaviors, e.g., grooming, shivering or immobility. In the rabbit and guinea pig type 2 theta can readily be elicited in unrestrained animals. However… Expand
Sensitization and hippocampal type 2 theta in the rat
Data was used to support the hypothesis that a state of arousal is a necessary precursor for the production of type 2 theta and inescapable shock when the temporal characteristics of the conditioning stimulus (CS) were varied. Expand
Immobility-related hippocampal theta activity in rats during reaction to novelty.
The purpose of the present study was to investigate whether Type 2 theta may occur in rats encountering novelty, and to shed light on this issue rats were tested in a novelty test in which smell made up the novel aspect. Expand
Alpha2 modulation of type 1 and type 2 hippocampal theta in the freely moving rat
Abstract In order to determine the brain sites involved in the noradrenergic modulation of hippocampal theta, the alpha2 agonist detomidine was infused into one of three brain sites in the freelyExpand
Hippocampal Formation Theta Activity and Movement Selection
Hippocampal theta activity results from activation in the ascending synchronizing system and is involved in the organization of motor behaviour, providing evidence that these neural systems are involved in signal processing relevant to movements underlying adaptive behaviour. Expand
Hippocampal theta oscillations are modulated by behaviour in the ferret but persist during both locomotion and immobility
It is shown that theta oscillations occur during locomotion in both the ferret and rat, however during periods of immobility, theTA oscillations persisted in the ferrets, contrasting starkly with the switch to large irregular activity (LIA) in the rat. Expand
The lateral septum as a regulator of hippocampal theta oscillations and defensive behavior in rats.
A novel role is revealed of the LS, especially its dorsal aspects, as an important gating mechanism for the expression of theta oscillations in the rodent hippocampus, and the fact that dLS-muscimol increased theta frequency while also reducing anxiety-like behaviors challenges the influential theta suppression model of anxiolysis. Expand
The effects of alpha2 agonists and antagonists on hippocampal theta activity in the freely moving rat
Abstract The alpha 2 agonists detomidine and xylazine were given to freely moving rats implanted with bilateral hippocampal recording electrodes. These alpha 2 agonists produced virtually continuousExpand
Behaviourally modulated hippocampal theta oscillations in the ferret persist during both locomotion and immobility
It is shown that theta oscillations occur during locomotion in both ferrets and rats, however during periods of immobility, theTA oscillations persisted in the ferret, contrasting starkly with the switch to large irregular activity (LIA) in the rat. Expand
Hippocampal Theta: a Sensory-inhibition Theory of Function
  • R. Sainsbury
  • Medicine, Psychology
  • Neuroscience & Biobehavioral Reviews
  • 1998
It is argued that the most parsimonious hypothesis relating theta to behavior is not the motor programming theory but a sensory-inhibition model. Expand
Alpha2-noradrenergic modulation of hippocampal theta activity
The inhibitory effect of norepinephrine on hippocampal type 2 theta activity was found to be mediated by alpha 2-adrenergic receptors and was blocked by microinfusions of an alpha 2 antagonist (tolazoline), which indicates that the site of action was specific to the noradren allergic alpha 2 receptor. Expand


The relationship between type 2 theta and behavior
Guinea pigs were exposed to three high "arousal" situations that produced reliable trains of "Type 2" theta, and a stimulus which had not previously elicited Type 2 theta was presented a second time after a presentation of a stimuli which did elicit Type 1 theta. Expand
Two types of hippocampal rhythmical slow activity in both the rabbit and the rat: Relations to behavior and effects of atropine, diethyl ether, urethane, and pentobarbital
Atropine-resistant activation of the cerebrum may play a role in the emission and control of normal behavior and may mediate many of the behavioral effects of centrally acting drugs such as anesthetics, tranquilizers, or stimulants. Expand
Hippocampal activity during natural behavior in the guinea pig.
Results were consistent with the theory that RSA accompanies voluntary behavior, but do not support the notion that RSA is indicative of a state of arousal. Expand
The use of sodium pentobarbital for the study of immobility-related (type 2) hippocampal theta
The effect of pentobarbital provides further evidence for species differences in the way the hippocampal formation produces Type 2 theta in rats and rabbits implanted with tungsten microelectrodes. Expand
Hippocampal electrical activity and voluntary movement in the rat.
  • C. H. Vanderwolf
  • Psychology, Medicine
  • Electroencephalography and clinical neurophysiology
  • 1969
It is suggested that rhythmical slow activity in the hippocampus and diencephalon are the electrical sign of activity in a forebrain mechanism which organizes or initiates higher (voluntary) motor acts. Expand
Hippocampal rhythmic slow activity (RSA, theta): A critical analysis of selected studies and discussion of possible species-differences
  • T. Robinson
  • Medicine, Psychology
  • Brain Research Reviews
  • 1980
The literature concerning the correlates of hippocampal RSA (theta) has seen a wealth of hypotheses generated from seemingly contradictory data, so the answer to the question as to whether there are species differences in the occurrence of RSA may be yes or not, depending upon how specifically the question is posed. Expand
Ontogeny of fascia dentata electrical activity and motor behavior in the dutch belted rabbit (Oryctolagus cuniculus)
It was demonstrated that in very young rabbits (between 8 and 15 days of age) atropine sulfate was nonselective in its effects, abolishing both movement-correlated theta (type 1) and immobility-related theTA (type 2). Expand
Neocortical and hippocampal activation in relation to behavior: Effects of atropine, eserine, phenothiazines, and amphetamine.
Evidence is presented to suggest that the hippocampus receives 2 nonspecific inputs from the brainstem, each capable of producing rhythmical slow activity. The neocortex appears to receive 2 similarExpand