Behavioral characterization of the novel GABAB receptor-positive modulator GS39783 (N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine): anxiolytic-like activity without side effects associated with baclofen or benzodiazepines.

@article{Cryan2004BehavioralCO,
  title={Behavioral characterization of the novel GABAB receptor-positive modulator GS39783 (N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine): anxiolytic-like activity without side effects associated with baclofen or benzodiazepines.},
  author={John F Cryan and Peter H. Kelly and Fr{\'e}d{\'e}rique Chaperon and Conrad Gentsch and C{\'e}dric Mombereau and Kurt Lingenhoehl and Wolfgang Froestl and Bernhard Bettler and Klemens Kaupmann and Will Spooren},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2004},
  volume={310 3},
  pages={
          952-63
        }
}
The role of GABAB receptors in various behavioral processes has been largely defined using the prototypical GABAB receptor agonist baclofen. However, baclofen induces sedation, hypothermia and muscle relaxation, which may interfere with its use in behavioral paradigms. Although there is much evidence for a role of the inhibitory neurotransmitter GABA in the pathophysiology of anxiety, the role of GABAB receptors in these disorders is largely unclear. We recently identified GS39783 (N,N… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 74 CITATIONS

Role of GABAB receptors in learning and memory and neurological disorders

  • Neuroscience & Biobehavioral Reviews
  • 2016
VIEW 11 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2004
2018

CITATION STATISTICS

  • 17 Highly Influenced Citations

  • Averaged 3 Citations per year over the last 3 years

References

Publications referenced by this paper.
SHOWING 1-10 OF 41 REFERENCES

GABAergic influences on plus-maze behaviour in mice

  • Psychopharmacology
  • 1996
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

A (2003) Non-nicotinic neuropharmacological strategies for nicotine dependence: beyond bupropion

JF Cryan, F Gasparini, G van Heeke, Markou
  • Drug Discov Today
  • 2003
VIEW 2 EXCERPTS

The neurobiology and control of anxious states

  • Progress in Neurobiology
  • 2003
VIEW 1 EXCERPT

Similar Papers

Loading similar papers…