Behavioral characterization of mice lacking the neurite outgrowth inhibitor Nogo-A.

@article{Willi2009BehavioralCO,
  title={Behavioral characterization of mice lacking the neurite outgrowth inhibitor Nogo-A.},
  author={Roman Willi and Elisabeth M Aloy and Benjamin K. Yee and Joram Feldon and Martin E. Schwab},
  journal={Genes, brain, and behavior},
  year={2009},
  volume={8 2},
  pages={
          181-92
        }
}
The membrane protein Nogo-A inhibits neurite outgrowth and regeneration in the injured central nervous system, primarily because of its expression in oligodendrocytes. Hence, deletion of Nogo-A enhances regeneration following spinal cord injury. Yet, the effects of Nogo-A deletion on general behavior and cognition have not been explored. The possibility of potential novel functions of Nogo-A beyond growth inhibition is strongly suggested by the presence of subpopulations of neurons also… CONTINUE READING

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