Behavioral characterization of dopamine D5 receptor null mutant mice.

@article{Holmes2001BehavioralCO,
  title={Behavioral characterization of dopamine D5 receptor null mutant mice.},
  author={A. J. Holmes and Tom R Hollon and Tierney Gleason and Zhong Liu and Jennifer L. Dreiling and David R. Sibley and Jacqueline N. Crawley},
  journal={Behavioral neuroscience},
  year={2001},
  volume={115 5},
  pages={
          1129-44
        }
}
To study behavioral functions of the D5 subtype, mice were generated with null mutations in the D5 gene. This 1st behavioral characterization of D5 null mutant mice (D5-/-) indicated normal general health, sensory abilities, and neurological reflexes. Under basal conditions, D5-/- mice were generally normal on locomotor activity, the rotarod test, acoustic startle response, prepulse inhibition, elevated plus-maze, light <--> dark exploration, Morris water maze, and cued and contextual fear… CONTINUE READING

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