Behavioral characterization of CD26 deficient mice in animal tests of anxiety and antidepressant-like activity.

@article{Yacoubi2006BehavioralCO,
  title={Behavioral characterization of CD26 deficient mice in animal tests of anxiety and antidepressant-like activity.},
  author={Malika El Yacoubi and J. -M. Vaugeois and Didier Marguet and Nicole Sauze and R{\'e}gis P Guieu and Jean Costentin and Emmanuel Fenouillet},
  journal={Behavioural brain research},
  year={2006},
  volume={171 2},
  pages={279-85}
}
CD26 exhibits a dipeptidylpeptidase-IV function (DPPIV) which regulates neuropeptide activity by N-terminal processing. Because abnormal plasma DPPIV was associated in mammals with behavioral changes, we examined the behavior of CD26-/- mice resulting from targeted inactivation of the gene. These animals had a decreased immobility in the forced swim and tail suspension tests, indicating a reduced depression-like behavior. We addressed some factors that could affect these results. No major… CONTINUE READING
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