Behavioral changes and trigeminal ganglion sodium channel regulation in an orofacial neuropathic pain model

@article{Eriksson2005BehavioralCA,
  title={Behavioral changes and trigeminal ganglion sodium channel regulation in an orofacial neuropathic pain model},
  author={Jonas Eriksson and Aleksandra Jablonski and Anna-Karin M Persson and J Hao and Kaj Fried},
  journal={Pain},
  year={2005},
  volume={119},
  pages={82-94}
}
We used a photochemical method to generate a partial ischemic injury to the infraorbital branch of the trigeminal nerve in rats. Following injury, rats developed a bilateral persistent hypersensitivity to mechanical stimulation in the territory innervated by the infraorbital nerve. In addition, spread of mechanical hypersensitivity beyond the facial region was noted. Heat hypersensitivity was also present, although to a lesser extent and of a shorter duration. In some rats, excessive facial… CONTINUE READING
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