Behavioral and regulatory abnormalities in mice deficient in the NPAS1 and NPAS3 transcription factors.

@article{ErbelSieler2004BehavioralAR,
  title={Behavioral and regulatory abnormalities in mice deficient in the NPAS1 and NPAS3 transcription factors.},
  author={Claudia Erbel-Sieler and Carol A. Dudley and Yudong Zhou and Xinle Wu and Sandi Jo Estill and Tina W. Han and Ramon Diaz-Arrastia and Eric W. Brunskill and S. Steven Potter and Steven L. McKnight},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 37},
  pages={13648-53}
}
Laboratory mice bearing inactivating mutations in the genes encoding the NPAS1 and NPAS3 transcription factors have been shown to exhibit a spectrum of behavioral and neurochemical abnormalities. Behavioral abnormalities included diminished startle response, as measured by prepulse inhibition, and impaired social recognition. NPAS1/NPAS3-deficient mice also exhibited stereotypic darting behavior at weaning and increased locomotor activity. Immunohistochemical staining assays showed that the… CONTINUE READING

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