Behavioral and physiologic effects of short-term and long-term administration of clonidine in panic disorder.

@article{Uhde1989BehavioralAP,
  title={Behavioral and physiologic effects of short-term and long-term administration of clonidine in panic disorder.},
  author={Thomas W. Uhde and Murray B. Stein and Bernard J Vittone and Larry J. Siever and J. P. Boulenger and Ehud Klein and Thomas Alan Mellman},
  journal={Archives of general psychiatry},
  year={1989},
  volume={46 2},
  pages={170-7}
}
We evaluated the behavioral and physiologic effects of clonidine hydrochloride, a centrally active alpha 2-adrenergic agonist, in two separate studies of patients with panic disorder. In the first study, intravenous clonidine (2 micrograms/kg) and placebo were administered on a blind basis to 12 patients with panic disorder and ten normal controls… CONTINUE READING