Behavioral and pharmacokinetic interaction between morphine and haloperidol in the rat.

@article{Adamus1984BehavioralAP,
  title={Behavioral and pharmacokinetic interaction between morphine and haloperidol in the rat.},
  author={Anna Adamus and Mirosŀawa Melzacka and Jerzy Vetulani},
  journal={Polish journal of pharmacology and pharmacy},
  year={1984},
  volume={36 1},
  pages={51-8}
}
Tail-flick latencies and morphine concentrations in the blood serum, brain (without striatum) and spinal cord were measured in rats receiving 10 mg/kg ip morphine with or without haloperidol pretreatment (0.1 or 1 mg/kg sc). Haloperidol pretreatment dose-dependently potentiated the analgesic action of morphine and interfered with tissue morphine levels… CONTINUE READING