Behavioral and neurophysiological effects of Ro 10-5824, a dopamine D4 receptor partial agonist, in common marmosets

  title={Behavioral and neurophysiological effects of Ro 10-5824, a dopamine D4 receptor partial agonist, in common marmosets},
  author={Shunsuke Nakazawa and Takeshi Murai and Masanori Miyauchi and Manato Kotani and Kazuhito Ikeda},
RationaleGrowing evidence suggests that dopamine D4 receptors (D4Rs) are involved in controlling executive functions. We have previously demonstrated that Ro 10-5824, a D4R partial agonist, improves the performance of common marmosets in the object retrieval detour (ORD) task. However, the neural mechanisms underlying this improvement are unknown.ObjectivesWe investigated the behavioral and neurophysiological effects of Ro 10-5824 in common marmosets.MethodsThe effects of Ro 10-5824 on… 

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  • Hidehiko TakahashiM. YamadaT. Suhara
  • Psychology, Biology
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 2012
Observations suggest that the variability of available D1 receptors might be associated with individual differences in brain functions that require phasic dopamine release, and an interdisciplinary approach combining molecular imaging of dopamine neurotransmission with cognitive neuroscience and clinical psychiatry will provide new perspectives for understanding the neurobiology of neuropsychiatric disorders.

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