Behavioral and neurochemical characterization of transgenic mice carrying the human presenilin-1 gene with or without the leucine-to-proline mutation at codon 235

@article{Huang2003BehavioralAN,
  title={Behavioral and neurochemical characterization of transgenic mice carrying the human presenilin-1 gene with or without the leucine-to-proline mutation at codon 235},
  author={Xian-zhang Huang and Benjamin K. Yee and Sangram Nag and Stephanie Ying Hui. Chan and F. C. Archie Tang},
  journal={Experimental Neurology},
  year={2003},
  volume={183},
  pages={673-681}
}
Human presenilin-1 (PS1) mutations are associated with the incidence of familial Alzheimer's disease. The present study evaluated the behavioral and neurochemical effects of the L235P mutation (substitution of leucine by proline at codon 235) of the human PS1 gene, which has been linked to a form of early-onset Alzheimer's disease. Except for a significant increase in the production of beta-amyloid-42, the mutant mice did not show any overt signs of Alzheimer-like neuropathology in the form of… CONTINUE READING
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