Behavioral and morphological responses to cocaine require kalirin7.

  title={Behavioral and morphological responses to cocaine require kalirin7.},
  author={Drew D Kiraly and Xin-ming Ma and Christopher M. Mazzone and Xiaonan Xin and Richard E Mains and Betty A Eipper},
  journal={Biological psychiatry},
  volume={68 3},
BACKGROUND Long-lasting increases in dendritic spine density and gene expression in the nucleus accumbens and in the ambulatory response to cocaine occur following chronic cocaine treatment. Despite numerous reports of these findings, the molecular mechanisms leading to these morphological, biochemical, and behavioral changes remain unclear. METHODS We used mice genetically lacking Kalirin7 (Kal7(KO)), a Rho guanine nucleotide exchange factor that regulates dendritic spine formation and… CONTINUE READING
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