Behavioral and molecular evidence for psychotropic effects in l-theanine

@article{Wakabayashi2011BehavioralAM,
  title={Behavioral and molecular evidence for psychotropic effects in l-theanine},
  author={C. Wakabayashi and T. Numakawa and M. Ninomiya and S. Chiba and H. Kunugi},
  journal={Psychopharmacology},
  year={2011},
  volume={219},
  pages={1099-1109}
}
Rationalel-Theanine (N-ethyl-l-glutamine) is an amino acid uniquely found in green tea and historically considered to be a relaxing agent. It is a glutamate derivative and has an affinity for glutamatergic receptors. However, its psychotropic effects remain unclear.ObjectivesTo elucidate effects of l-theanine on psychiatric disease-related behaviors in mice and its molecular basis focusing on brain-derived neurotrophic factor (BDNF) and N-methyl-d-aspartate (NMDA) receptor.MethodsWe examined… Expand
34 Citations

Paper Mentions

Interventional Clinical Trial
Major depressive disorder (MDD) is a serious mental illness and the leading cause of disability worldwide. New pharmacotherapeutic agents with complementary neurobiological… Expand
ConditionsCortical Excitability, Psychiatric Disorder
InterventionDrug
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Glycine and d-serine, but not d-cycloserine, attenuate prepulse inhibition deficits induced by NMDA receptor antagonist MK-801
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