Behavioral and molecular evidence for psychotropic effects in l-theanine

  title={Behavioral and molecular evidence for psychotropic effects in l-theanine},
  author={C. Wakabayashi and T. Numakawa and Midori Ninomiya and S. Chiba and H. Kunugi},
  • C. Wakabayashi, T. Numakawa, +2 authors H. Kunugi
  • Published 2011
  • Medicine, Psychology
  • Psychopharmacology
  • Rationalel-Theanine (N-ethyl-l-glutamine) is an amino acid uniquely found in green tea and historically considered to be a relaxing agent. It is a glutamate derivative and has an affinity for glutamatergic receptors. However, its psychotropic effects remain unclear.ObjectivesTo elucidate effects of l-theanine on psychiatric disease-related behaviors in mice and its molecular basis focusing on brain-derived neurotrophic factor (BDNF) and N-methyl-d-aspartate (NMDA) receptor.MethodsWe examined… CONTINUE READING
    33 Citations

    Paper Mentions

    Interventional Clinical Trial
    Major depressive disorder (MDD) is a serious mental illness and the leading cause of disability worldwide. New pharmacotherapeutic agents with complementary neurobiological… Expand
    ConditionsCortical Excitability, Psychiatric Disorder
    l-theanine attenuates abstinence signs in morphine-dependent rhesus monkeys and elicits anxiolytic-like activity in mice
    • 9
    • Highly Influenced
    Theanine enhanced both the toxicity of strychnine and anticonvulsion of pentobarbital sodium
    • 2
    Effect of l-theanine on glutamatergic function in patients with schizophrenia
    • 20
    Effects of chronic l-theanine administration in patients with major depressive disorder: an open-label study
    • 34
    • PDF


    The Neuropharmacology of L-Theanine(N-Ethyl-L-Glutamine)
    • 80
    Anxiolytic effects of L-theanine--a component of green tea--when combined with midazolam, in the male Sprague-Dawley rat.
    • 22
    • PDF
    Glycine and d-serine, but not d-cycloserine, attenuate prepulse inhibition deficits induced by NMDA receptor antagonist MK-801
    • 48
    l-Theanine reduces psychological and physiological stress responses
    • 241
    • PDF
    Involvement of GABA(A) receptors in the neuroprotective effect of theanine on focal cerebral ischemia in mice.
    • 35
    Antidepressant‐like Effects of L‐theanine in the Forced Swim and Tail Suspension Tests in Mice
    • 41