Behavioral and molecular evidence for psychotropic effects in l-theanine

@article{Wakabayashi2011BehavioralAM,
  title={Behavioral and molecular evidence for psychotropic effects in l-theanine},
  author={C. Wakabayashi and T. Numakawa and Midori Ninomiya and S. Chiba and H. Kunugi},
  journal={Psychopharmacology},
  year={2011},
  volume={219},
  pages={1099-1109}
}
  • C. Wakabayashi, T. Numakawa, +2 authors H. Kunugi
  • Published 2011
  • Medicine, Psychology
  • Psychopharmacology
    • Rationalel-Theanine (N-ethyl-l-glutamine) is an amino acid uniquely found in green tea and historically considered to be a relaxing agent. It is a glutamate derivative and has an affinity for glutamatergic receptors. However, its psychotropic effects remain unclear.ObjectivesTo elucidate effects of l-theanine on psychiatric disease-related behaviors in mice and its molecular basis focusing on brain-derived neurotrophic factor (BDNF) and N-methyl-d-aspartate (NMDA) receptor.MethodsWe examined… CONTINUE READING
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    33 Citations
    Highly Influential Citations
    1
    Background Citations
    14
    Methods Citations
    1
    Results Citations
    5

    Paper Mentions

    Interventional Clinical Trial
    Effects of L-theanine on Motor Cortex Excitability in Healthy Subjects: A Paired-Pulse TMS Study
    Major depressive disorder (MDD) is a serious mental illness and the leading cause of disability worldwide. New pharmacotherapeutic agents with complementary neurobiological… Expand
    ConditionsCortical Excitability, Psychiatric Disorder
    InterventionDrug
    Butler Hospital
    June 2020 - May 2021
    33 Citations
    Citation Type

    Citation Type

    Effects of l-theanine on anxiety-like behavior, cerebrospinal fluid amino acid profile, and hippocampal activity in Wistar Kyoto rats
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    Neurobiological effects of the green tea constituent theanine and its potential role in the treatment of psychiatric and neurodegenerative disorders
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    Characterization of l-Theanine Excitatory Actions on Hippocampal Neurons: Toward the Generation of Novel N-Methyl-d-aspartate Receptor Modulators Based on Its Backbone.
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    Psychotropic effects of L-theanine and its clinical properties: From the management of anxiety and stress to a potential use in schizophrenia.
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    l-theanine attenuates abstinence signs in morphine-dependent rhesus monkeys and elicits anxiolytic-like activity in mice
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    Theanine enhanced both the toxicity of strychnine and anticonvulsion of pentobarbital sodium
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    Effect of l-theanine on glutamatergic function in patients with schizophrenia
    • 20
    Effects of chronic l-theanine administration in patients with major depressive disorder: an open-label study
    • 34
    • PDF
    L‐theanine ameliorate depressive‐like behavior in a chronic unpredictable mild stress rat model via modulating the monoamine levels in limbic–cortical–striatal–pallidal–thalamic‐circuit related brain regions
    • 9
    Possible role of the dopamine D1 receptor in the sensorimotor gating deficits induced by high-fat diet
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