Behavioral and molecular evidence for psychotropic effects in l-theanine
@article{Wakabayashi2011BehavioralAM, title={Behavioral and molecular evidence for psychotropic effects in l-theanine}, author={C. Wakabayashi and T. Numakawa and M. Ninomiya and S. Chiba and H. Kunugi}, journal={Psychopharmacology}, year={2011}, volume={219}, pages={1099-1109} }
Rationalel-Theanine (N-ethyl-l-glutamine) is an amino acid uniquely found in green tea and historically considered to be a relaxing agent. It is a glutamate derivative and has an affinity for glutamatergic receptors. However, its psychotropic effects remain unclear.ObjectivesTo elucidate effects of l-theanine on psychiatric disease-related behaviors in mice and its molecular basis focusing on brain-derived neurotrophic factor (BDNF) and N-methyl-d-aspartate (NMDA) receptor.MethodsWe examined… Expand
Paper Mentions
Interventional Clinical Trial
Major depressive disorder (MDD) is a serious mental illness and the leading cause of
disability worldwide. New pharmacotherapeutic agents with complementary neurobiological… Expand
Conditions | Cortical Excitability, Psychiatric Disorder |
---|---|
Intervention | Drug |
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References
SHOWING 1-10 OF 65 REFERENCES
The neuropharmacology of L-theanine(N-ethyl-L-glutamine): a possible neuroprotective and cognitive enhancing agent.
- Chemistry
- 2006
- 100
The Neuropharmacology of L-Theanine(N-Ethyl-L-Glutamine)
- Chemistry, Medicine
- Journal of herbal pharmacotherapy
- 2006
- 80
Anxiolytic effects of L-theanine--a component of green tea--when combined with midazolam, in the male Sprague-Dawley rat.
- Medicine
- AANA journal
- 2009
- 22
- PDF
Glycine and d-serine, but not d-cycloserine, attenuate prepulse inhibition deficits induced by NMDA receptor antagonist MK-801
- Medicine
- Psychopharmacology
- 2008
- 48
l-Theanine reduces psychological and physiological stress responses
- Medicine
- Biological Psychology
- 2007
- 245
- PDF
Modulators of the glycine site on NMDA receptors, d-serine and ALX 5407, display similar beneficial effects to clozapine in mouse models of schizophrenia
- Chemistry, Medicine
- Psychopharmacology
- 2005
- 150
- PDF
Involvement of GABA(A) receptors in the neuroprotective effect of theanine on focal cerebral ischemia in mice.
- Medicine
- Journal of pharmacological sciences
- 2007
- 35
Antidepressant‐like Effects of L‐theanine in the Forced Swim and Tail Suspension Tests in Mice
- Chemistry, Medicine
- Phytotherapy research : PTR
- 2011
- 44
Effects of aripiprazole on MK-801-induced prepulse inhibition deficits and mitogen-activated protein kinase signal transduction pathway
- Chemistry, Medicine
- Neuroscience Letters
- 2010
- 31