Behavioral and immunohistochemical effects of chronic intravenous and subcutaneous infusions of varying doses of rotenone

@article{Fleming2004BehavioralAI,
  title={Behavioral and immunohistochemical effects of chronic intravenous and subcutaneous infusions of varying doses of rotenone},
  author={Sheila M. Fleming and Chunni Zhu and Pierre-Olivier Fernagut and Arpesh Mehta and M F Chesselet},
  journal={Experimental Neurology},
  year={2004},
  volume={187},
  pages={418-429}
}
Mitochondrial toxins such as the complex 1 inhibitor rotenone are widely used as pesticides and may be present in military environments. Administration of rotenone can induce biochemical and histological alterations similar to those of Parkinson's disease in rats. However, only a subset of animals show these effects and it is unclear whether more subtle alterations are caused by chronic administration of rotenone in those animals that appear resistant to its toxic effects on dopaminergic nerve… CONTINUE READING

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