Behavioral and endocrine changes following antisense oligonucleotide-induced reduction in the rat NOP receptor

@article{Blakley2004BehavioralAE,
  title={Behavioral and endocrine changes following antisense oligonucleotide-induced reduction in the rat NOP receptor},
  author={Gregory G. Blakley and Larissa A. Pohorecky and Daniel E. Benjamin},
  journal={Psychopharmacology},
  year={2004},
  volume={171},
  pages={421-428}
}
Compared with the use of classic receptor ligands, antisense oligonucleotides (ASO) targeted at specific central nervous system receptors are an effective alternative in experiments designed to examine the behavioral role of such systems. The nociception/orphaninFQ (N/OFQ) system has been implicated in mediating endocrine function, feeding, stress, pain, anxiety, and the rewarding effects of drugs of abuse. The objective of the current study was to examine whether long-term ASO-induced… CONTINUE READING