Behavioral and developmental effects of two 3,4-methylenedioxymethamphetamine (MDMA) derivatives.

@article{Bronson1994BehavioralAD,
  title={Behavioral and developmental effects of two 3,4-methylenedioxymethamphetamine (MDMA) derivatives.},
  author={Maureen E. Bronson and L Barrios-Zambrano and W Jiang and C. Randall Clark and Jack Deruiter and M. Christopher Newland},
  journal={Drug and alcohol dependence},
  year={1994},
  volume={36 3},
  pages={
          161-6
        }
}
The effects of 3,4-methylenedioxymethamphetamine (MDMA or 'ecstacy') and two structurally related compounds, N-methyl-1-(3,4-methylenedioxyphenyl)-1-ethanamine (MDM1EA) and N-methyl-1-(3,4-methylenedioxyphenyl)-3-butanamine (HMDMA) were examined in two preparations: (i) a drug discrimination procedure in MDMA-trained rats and (ii) the chicken embryo, for determination of the direct effects of these compounds on the developing organism. The highest doses of MDM1EA and HMDMA partially substituted… Expand
Developmental effects of 3,4-methylenedioxymethamphetamine: a review
TLDR
Evidence shows that MDMA exposure has adverse effects on the developing brain and behavior, and the animal and human data on developmental MDMA exposure are reviewed. Expand
A developmental comparison of the neurobehavioral effects of ecstasy (MDMA).
  • B. Piper
  • Psychology, Medicine
  • Neurotoxicology and teratology
  • 2007
TLDR
Current evidence suggests adults are more sensitive to the long-term serotonin depletions following MDMA but younger ages also exhibit substantial and rapid neuroplasticity, while a reduction in body weight is evident at all ages. Expand
Neurobehavioral outcomes of infants exposed to MDMA (Ecstasy) and other recreational drugs during pregnancy.
TLDR
Women who used MDMA during pregnancy had fewer prior births and more negative sequelae associated with their drug use, including more health, work, and social problems, and risk to the developing infant related to MDMA exposure is suggested. Expand
Effects of MDMA on Complex Brain Function in Laboratory Animals
TLDR
Results of these experiments suggest that when given acutely, MDMA disrupts complex brain functions associated with learning and time estimation more than those associated with short-term memory and visual discrimination, and that behavioral tasks requiring relatively high rates of responding are particularly sensitive to the disruptive effects of MDMA. Expand
Thin Layer Chromatography/Fluorescence Detection of 3,4‐Methylenedioxy‐Methamphetamine and Related Compounds
TLDR
The proposed method was effectively applied to the detection of MDMA in urine samples and blue fluorescent spots were observed under ultraviolet light in a wavelength range of 250–400 nm. Expand
A Confiscation Case Involving a Novel Barbiturate Designer Drug
ABSTRACT An unknown drug was seized from a suspicious person. The drug appeared to be an analogue of phenobarbital, which is restricted by drug control laws. The structure of the seized drug wasExpand
LSD Produces Conditioned Place Preference in Male But Not Female Fawn Hooded Rats
TLDR
Results indicated that rats administered LSD while sequestered in the nonpreferred location spent more time in that location during a nondrug test, indicative of a conditioned place preference, was exhibited only in male animals. Expand

References

SHOWING 1-10 OF 15 REFERENCES
Stimulus effects of N-monoethyl-1-(3,4-methylenedioxyphenyl)-2-aminopropane (MDE) and N-hydroxy-1-(3,4-methylenedioxyphenyl)-2-aminopropane (N-OH MDA) in rats trained to discriminate MDMA from saline
TLDR
MDMA-stimulus generalization to MDE, N-OH MDA, but not to (+)amphetamine suggest that 1) MDMA produces effects other than those that may be considered amphetamine-like, and 2) MDE and N- OH MDA are MDMA-like agents with even less of an amp methamphetamine-like component of action than MDMA itself. Expand
Toxicity and deaths from 3,4-methylenedioxymethamphetamine ("ecstasy")
The risk of adverse reactions to 3,4-methylenedioxymethamphetamine (MDMA), more commonly known as "ecstasy", is now widely known in both the USA and UK, but the patterns of illness remain varied. WeExpand
Studies of MDMA-induced neurotoxicity in nonhuman primates: a basis for evaluating long-term effects in humans.
TLDR
Concern that MDMA may be neurotoxic in humans is heightened since the steepness of the dose-response curve of MDMA in the primate suggests a narrow margin of safety, and preclinical studies in monkeys have shown that CSF 5-HIAA can be used to detect MDMA-induced serotonergic damage in thePrimate CNS. Expand
Centrally active N-substituted analogs of 3,4-methylenedioxyphenylisopropylamine (3,4-methylenedioxyamphetamine).
TLDR
Measurements of the pharmacological activity of a series of analogs with substituents on the nitrogen atom indicated that the central activity decreased with the increasing bulk of the N-substituent. Expand
Liquid chromatographic and mass spectral analysis of 1-(3,4-methylenedioxyphenyl)-3-butanamines, homologues of 3,4-methylenedioxyamphetamines.
TLDR
The 1-(3,4-methylenedioxyphenyl)-3-butanamines (HMDAs) are prepared via reductive amination of the corresponding ketone with a series of low molecular weight alkylamines that have UV absorption properties similar to the MDAs. Expand
Liquid chromatographic and mass spectral analysis of 1-(3,4-methylenedioxyphenyl)-3-butanamines, homologues of 3,4-methylenedioxyamphetamines.
The 1-(3,4-methylenedioxyphenyl)-3-butanamines (HMDAs) are prepared via reductive amination of the corresponding ketone with a series of low molecular weight alkylamines. These amines are homologuesExpand
Abuse liability studies of opioid agonist-antagonists in humans.
TLDR
Three assessment methods, subjective effect measurement, self-administration and drug discrimination, provide information relevant to measuring reinforcing efficacy, a major determinant of the degree to which a drug is sought and self- administered by abusers, suggesting that these methods are useful in predicting abuse liability of novel opioids. Expand
Structure‐Activity Relationships of MDMA and Related Compounds: A New Class of Psychoactive Drugs? a
TLDR
Evidence will be presented to support the view that the pharmacology of entactogens is clearly different from other known classes of compounds. Expand
Liquid chromatographic and mass spectral analysis of N-substituted analogues of 3,4-methylenedioxyamphetamine.
The C1 to C3 N-alkyl, N,N-dimethyl, and N-hydroxy analogues of 3,4-methylenedioxyamphetamine (MDA) are identified by high performance liquid chromatographic (HPLC) and spectrometric techniques. TheExpand
Assessment of abuse liability of stimulant drugs in humans: a methodological survey.
TLDR
The behavioral effects of a number of stimulant drugs will be compared along these dimensions and the effects along each dimension will be related to each drugs' known abuse liability. Expand
...
1
2
...