Behavioral and biochemical effects of glutathione depletion in the rat brain.

@article{CruzAguado2001BehavioralAB,
  title={Behavioral and biochemical effects of glutathione depletion in the rat brain.},
  author={Reyniel Cruz-Aguado and William Almaguer-Melian and Carmen M. D{\'i}az and Lourdes del C Lorigados and Jorge A. Bergado},
  journal={Brain research bulletin},
  year={2001},
  volume={55 3},
  pages={327-33}
}
Glutathione serves the function of providing reducing equivalents for the maintenance of oxidant homeostasis, and besides it plays roles in intra- and intercellular signaling in the brain. Our purpose was to test the effects of depleting tissue glutathione by diethylmaleate (5.3 mmol/kg, intraperitoneal) on brain antioxidant metabolism, nerve growth factor levels, and cognitive performance in rats. Six hours after the treatment, glutathione level in the hippocampus dropped down to 30% of the… CONTINUE READING

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