Behavioral and biochemical effects of chronic Δ9-tetrahydrocannabinol in rats

@article{Miczek1980BehavioralAB,
  title={Behavioral and biochemical effects of chronic Δ9-tetrahydrocannabinol in rats},
  author={Klaus A Miczek and Balwant N. Dixit},
  journal={Psychopharmacology},
  year={1980},
  volume={67},
  pages={195-202}
}
In an attempt to identify the possible role of brain biogenic amines and adrenocorticotrophic hormone (ACTH) release in the behavioral and physiological effects of Δ9-tetrahydrocannabinol (THC), the time course of drug action was studied. THC (20 mg/kg) was administered daily for 1, 4, 21, or 42 days to Sprague-Dawley rats that were examined for changes in body temperature, food and water intake, rearing and walking activity, compulsive motor routines, and mouse killing. Four hours after the… CONTINUE READING

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