Behavioral and Neurochemical Characteristics of Two Months Old WAG/Rij Rats with Genetic Absence Epilepsy
@article{Fedosova2015BehavioralAN, title={Behavioral and Neurochemical Characteristics of Two Months Old WAG/Rij Rats with Genetic Absence Epilepsy}, author={Ekaterina Fedosova and Karine Yu. Sarkisova and Vladimir S Kudrin and Viktor B. Narkevich and Ara S. Bazyan}, journal={Clinical and experimental neurology}, year={2015}, volume={3}, pages={32-44} }
WAG/Rij rats are genetic animal model of absence epilepsy with comorbidity of depression. The first spike-wave discharges (SWDs) in WAG/Rij rats begin to appear at the age of 2-3 months and are fully manifested by 5-6 months. Occurrence of SWDs in the EEG is the main index of absence epilepsy. Previously it has been shown that the extensive absence epilepsy in 5-6 months old WAG/Rij rats is accompanied by decrease of dopamine and its metabolites concentrations in the meso-cortico-limbic and…
2 Citations
Ethosuximide Increases Exploratory Motivation and Improves Episodic Memory in the Novel Object Recognition Test in WAG/Rij Rats with Genetic Absence Epilepsy
- Psychology, BiologyNeuroscience and Behavioral Physiology
- 2021
Evidence is provided that impairments to episodic memory in the novel object recognition test in WAG/Rij rats may be due to decreased exploratory motivation as one of the symptoms of depression comorbid with absence epilepsy.
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