Behavioral and Neurochemical Alterations After Lithium–Pilocarpine Administration in Young and Adult Rats: A Comparative Study

@article{Bruin2000BehavioralAN,
  title={Behavioral and Neurochemical Alterations After Lithium–Pilocarpine Administration in Young and Adult Rats: A Comparative Study},
  author={Veralice Meireles Sales Bruin and Mar{\'i}a Manuela Marinho and Francisca Cl{\'e}a Florenço Sousa and Glauce Socorro de Barros Viana},
  journal={Pharmacology Biochemistry and Behavior},
  year={2000},
  volume={65},
  pages={547-551}
}
Pilocarpine and lithium-pilocarpine can induce seizures and brain damage in adult rats. However, manifestation of cerebral lesions seems to be an age-related phenomenon suggesting that maturational states of neurocircuitry may be involved. We have studied behavior changes, cerebral histopathology, and muscarinic and dopaminergic receptors density in rodents subjected to lithium-pilocarpine treatment. Wistar rats, at two different ages (21 days and 2 months), were treated with pilocarpine (15 mg… CONTINUE READING